Systems and methods for on-line finishing of cellular blood...

A - Human Necessities – 61 – K

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A61K 35/16 (2006.01) A61M 1/36 (2006.01) B01D 21/00 (2006.01) C12M 1/10 (2006.01) C12Q 1/24 (2006.01) C12S 3/22 (2006.01)

Patent

CA 2214146

Blood processing systems and methods establish on-line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field (14) between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device (24). The finishing device (24) changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The system and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on-line communication between the container and the source of blood.

Des systèmes et des procédés de fractionnement du sang établissent une communication en ligne entre un conteneur et une source de sang contenant des leucocytes et des plaquettes, telle qu'un donneur humain. Ces systèmes et procédés créent, entre la source de sang et le conteneur, un champ centrifuge (14) qui sépare du sang une suspension de plaquettes non finie dont les caractéristiques physiologiques premières diffèrent des caractéristiques physiologiques désirées. Ces systèmes et procédés pompent la suspension de plaquettes non finie hors du champ centrifuge au travers d'un appareil de finissage (24). Ledit appareil de finissage (24) transforme la caractéristique physiologique première en caractéristique physiologique désirée, et ce faisant, crée la suspension de plaquettes finie. Ces systèmes et procédés transfèrent la suspension de plaquettes finie de l'appareil de finissage directement dans le conteneur. Ces systèmes et procédés fonctionnent sans qu'il soit nécessaire d'interrompre la communication en ligne établie entre le conteneur et la source de sang.

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