Novel diazabicyclic aryl derivatives as cholinergy ligands

C - Chemistry – Metallurgy – 07 – D

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C07D 487/08 (2006.01) A61K 31/4995 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2588961

This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

La présente invention a pour objet de nouveaux dérivés aryliques diazabicycliques qui sont des ligands cholinergiques vis-à-vis des récepteurs nicotiniques de l'acétylcholine et des régulateurs des récepteurs et des vecteurs de monoamines. Du fait de leur profil pharmacologique, les composés de l'invention peuvent être employés dans le traitement de maladies ou de troubles aussi variés que ceux liés au système cholinergique du système nerveux central (SNC), au système nerveux périphérique (SNP), aux maladies ou troubles liés à la contraction de muscles lisses, aux maladies ou troubles endocriniens, aux maladies ou troubles liés à la neurodégénérescence, aux maladies ou troubles liés à une inflammation, à la douleur, et aux symptômes de retrait causés par la fin d'une addiction à des substances chimiques.

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