A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/56 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2229345
The present invention provides a method of increasing the cellular expression of a gene in a biological tissue after delivery of said gene to an animal, comprising the step of: administering to said animal a pharmacologically effective dose of a glucocorticoid in an amount sufficient to increase the cellular expression of said gene. Also provided is a various method of treating a pathophysiological state in a human by increasing cellular expression of a gene after delivery of said gene into a biological tissue of an animal in need of such treatment, comprising the step of: administering to said animal a pharmacologically effective dose of a glucocorticoid in a amount sufficient to increase the cellular expression of said gene.
L'invention concerne un procédé permettant d'augmenter l'expression cellulaire d'un gène dans un tissu biologique après l'administration de ce gène à un animal. Ce procédé consiste à administrer à cet animal une dose pharmacologiquement efficace d'un glucocorticoïde en quantité suffisante pour augmenter l'expression cellulaire du gène concerné. L'invention se rapporte aussi à un procédé de traitement d'un état pathophysiologique chez l'homme, qui consiste à augmenter l'expression cellulaire d'un gène après l'insertion de ce gène dans un tissu biologique d'un animal nécessitant ce type de traitement. Ce procédé consiste à administrer à cet animal une dose pharmacologiquement efficace d'un glucocorticoïde en quantité suffisante pour augmenter l'expression cellulaire de ce gène.
Johnson Jennifer Lee
Knight Vernon
Schwarz Lindsay
Borden Ladner Gervais Llp
Research Development Foundation
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