Vascular endothelial growth factor 2

Details Vascular endothelial growth factor 2 Vascular endothelial growth factor 2

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) C07K 14/52 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2322748

Disclosed are human VEGF-2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF-2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides and polynucleotides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

L'invention concerne des polypeptides humains du facteur de croissance endothélial vasculaire 2, des fragments, analogues ou dérivés de ces polypeptides, actifs sur le plan biologique et utiles sur les plans diagnostique et thérapeutique, ainsi que l'ADN (ARN) codant ces polypeptides. L'invention concerne également des procédés de production de tels polypeptides à l'aide de techniques de recombinaison, de même que des anticorps et antagonistes dirigés contre de tels polypeptides. On peut utiliser ces polypeptides et polynucléotides de manière thérapeutique pour stimuler la cicatrisation de plaies et dans la réparation de tissus vasculaires. L'invention concerne encore des procédés d'utilisation de ces anticorps et antagonistes, destinés à inhiber l'angiogenèse de tumeurs et donc la croissance de celles-ci, l'inflammation, la rétinopathie diabétique, la polyarthrite rhumatoïde et le psoriasis.

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