Use of amidoxime carboxylic acid esters and...

A - Human Necessities – 61 – K

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Details

A61K 31/155 (2006.01) A61P 7/02 (2006.01) A61P 9/12 (2006.01) A61P 25/28 (2006.01) A61P 31/16 (2006.01) A61P 31/18 (2006.01) A61P 33/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2713784

The invention relates to a method for improving bioavailability of pharmaceutical substances and for allowing said pharmaceutical substances to permeate the blood-brain barrier, said pharmaceutical substances having at least one or more amidine, guanidine,N-hydroxyamidine (ami-doxime) or N-hydroxyguanidine-functions. The invention also relates to medicaments containing correspondingly modified pharmaceutical substances.

L'invention concerne : un procédé pour améliorer la biodisponibilité et permettre le passage par la barrière hémato-encéphalique de substances pharmaceutiques qui présentent au moins une ou plusieurs fonctions amidine, guanidine, N-hydroxyamidine (amidoxime) ou N-hydroxyguanidine ; et des médicaments contenant des substances pharmaceutiques modifiées en conséquence.

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