Benzoxazoles, benzthiazoles and related analogs as sirtuin...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 413/12 (2006.01) A61K 31/42 (2006.01) A61K 31/423 (2006.01) A61P 3/00 (2006.01) A61P 3/10 (2006.01) C07D 263/57 (2006.01) C07D 277/66 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2733966

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating com-pounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

L'invention porte sur de nouveaux composés modulant la sirtuine et sur des procédés d'utilisation de ceux-ci. Les composés modulant la sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et traiter et/ou prévenir une large diversité de maladies et de troubles comprenant, par exemple, des maladies ou des troubles liés à l'âge ou au stress, le diabète, l'obésité, des maladies neurodégénératives, des maladies cardiovasculaires, des maladies de coagulation du sang, une inflammation, un cancer et/ou des bouffées congestives ainsi que des maladies ou troubles qui bénéficieraient d'une activité mitochondriale accrue. L'invention porte également sur des compositions comprenant un composé modulant la sirtuine en combinaison avec un autre agent thérapeutique.

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