Derivatives of 1,3,4-oxadiazolone

Details Derivatives of 1,3,4-oxadiazolone Derivatives of 1,3,4-oxadiazolone

A - Human Necessities

61

K

A61K 31/41 (2006.01) C07D 271/113 (2006.01)

Patent

CA 2318830

The present invention provides novel oxadiazolone derivatives having general formula (I), wherein A, B, D and R are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of the large conductance calcium-activated potassium channels.

Cette invention, qui a trait à de nouveaux dérivés benzoate correspondant à la formule générale: dans laquelle A, B, D et R sont tels que définis dans le descriptif, concerne également un sel ou un solvate, non toxique et acceptable du point de vue pharmaceutique, de ces dérivés. Ces substances sont efficaces dans le cadre du traitement d'affections influencées par l'ouverture des canaux potassium à importante conductance activés par le calcium.

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