Piperidine derivatives as nmda receptor antagonists

Details Piperidine derivatives as nmda receptor antagonists Piperidine derivatives as nmda receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/451 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01) C07D 211/16 (2006.01) C07D 211/18 (2006.01) C07D 401/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2453383

The present invention relates to new carboxylic acid amide derivatives of formula (I), wherein U, V, W, X, Y, Z, n and m are as defined as in Claim 1. A further object of the invention are the processes for producing of carboxylic acid amide compounds of formula (I), and the pharmaceutical manufacture of medicaments containing these compounds, as well as the process of treatments with these compounds, which means administering to a mammal to be treated including human - effective amount/amounts of compounds of formula (I) of the present invention as such or as medicament. The new carboxylic acid amide derivatives of formula (I) of the present invention are highly effective and selective antagonists of NMDA receptor, and moreover most of the compounds are selective antagonist of NR2B subtype of NMDA receptor.

L'invention concerne de nouveaux dérivés amides d'acide carboxylique représentés par la formule (1), dans laquelle U, V, W, X, Y, Z, n et m sont définis de la même manière que dans la revendication (1). L'invention concerne également des procédés de production de composés amides d'acide carboxylique de formule (1), et la fabrication pharmaceutique de médicaments contenant ces composés, ainsi que le procédé de traitement de ces composés. Ce procédé de traitement consiste à administrer à un mammifère devant être traité - y compris un être humain - une quantité efficace de composés de formule (1) de cette invention comme médicament. Les nouveaux dérivés amides d'acide carboxylique de formule (1) de la présente invention sont des antagonistes sélectifs et hautement efficaces du récepteur de NMDA, et de plus, la plupart des composés sont des antagonistes sélectifs du sous-type NR2B du récepteur de NMDA.

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