1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)cytosine

Details 1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)cytosine 1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)cytosine

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) C07D 333/32 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2224155

The present invention relates to 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabino- furanosyl)cytosines having excellent antitumor activity, represented by formula [I]: (see formula I) wherein R represents a hydrogen atom or a phosphoric acid residue, and to a process for the production and use thereof.

Cette invention se rapporte à des 1-(2-désoxy-2-fluoro-4-thio- beta -D-arabinofuranosyl)cytosines représentées par la formule générale (I) qui possèdent une excellente activité antitumorale, ainsi qu'à un procédé de préparation de ces composés et à leur utilisation. Dans ladite formule (I), R est hydrogène ou un reste d'acide phosphorique.

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