Process for the preparation of ceftriaxon disodium salt...

Details Process for the preparation of ceftriaxon disodium salt... Process for the preparation of ceftriaxon disodium salt...

C - Chemistry, Metallurgy

07

D

C07D 501/56 (2006.01) C07D 501/00 (2006.01) C07D 501/18 (2006.01)

Patent

CA 2088173

11 ABSTRACT A new and improved process for the preparation of ceftriaxon disodium salt hemiheptahydrate of formula I Image I is described, wherein 7-amino-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-trazin- 3-yl)thio]methyl}-3-cephem-4-carboxylic acid disodium salt is converted with a reac- tive 2-(2-aminothiazol-4-yl)-2-syn-metoxyimino acetic acid derivative such as 2-benzo-thiazolyl-thio ester in a water solution and in the presence of a suitable inert organic solvent such as acetone, at a temperature between 0 °C and 40 °C and then the desired compound is isolated in a very pure form and with a high total yield. Ceftriaxon is a cephalosporin antibiotic of the third generation for parenteral ap- plication and a valuable agent for the treatment of heavy infections.

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