Compositions for purifying and crystallizing molecules of...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) C07K 1/14 (2006.01) C12N 15/10 (2006.01) C12Q 1/00 (2006.01) C30B 29/54 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2531492

A composition of matter is provided. The composition includes at least one ligand capable of binding a target molecule or cell of interest, the at least one ligand being attached to at least one coordinating moiety selected capable of directing the composition of matter to form a non-covalent complex when co- incubated with a coordinator ion or molecule. Also provided are methods of using such compositions for target purification, crystallization and immunization.

L'invention concerne une composition de matières. Cette composition comprend au moins un ligand capable de fixer une molécule cible ou une cellule donnée, le ligand étant couplé à au moins un fragment de coordination choisi, qui entraîne la formation d'un complexe non-covalent par la composition de matières lorsqu'elle est incubée conjointement à un ion ou à une molécule de coordination. L'invention concerne également des méthodes portant sur l'utilisation de compositions de ce type pour une purification, une cristallisation et une immunisation ciblées.

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