Electrophysiology configuration suitable for high throughput...

G - Physics – 01 – N

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G01N 33/487 (2006.01) C12M 1/34 (2006.01)

Patent

CA 2413663

The present invention provides apparatuses for measuring cell membrane resistance, conductance, potential, and capacitance, which can be used to determine cellular electrical activity. More specifically, the present invention provides automated apparatuses that are designed for high-throughput analysis of various compounds, ligands, and cell processes that modulate cellular electrical properties (e.g., cell membrane conditions). Such automated apparatuses can be used for the precise determination of ion channel activity, and for the rapid identification of compounds, ligands, or processes that alter this activity. The present invention also provides methods for measuring cellular electrical properties utilizing the apparatuses provided herein.

La présente invention concerne des appareils permettant de mesurer la résistance, la conductibilité, le potentiel et la capacité électrique de la membrane cellulaire, lesquelles paramètres peuvent servir à déterminer l'activité électrique de la cellule. La présente invention concerne, en particulier, des appareils automatiques conçus pour l'analyse à haut débit de divers composés, ligands et processus cellulaires qui modulent les propriétés électriques de la cellule (par exemple, conditions de la membrane cellulaire). Ces appareils automatiques peuvent servir à déterminer avec précision l'activité des canaux ioniques et à identifier rapidement des composés, ligands ou processus qui modifient cette activité. La présente invention concerne, en outre, des procédés de mesure des propriétés électriques de la cellule utilisant les appareils selon l'invention.

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