Isolated, mage-3 derived peptides which complex with hla-a2...

Details Isolated, mage-3 derived peptides which complex with hla-a2... Isolated, mage-3 derived peptides which complex with hla-a2...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 35/14 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C12N 5/08 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2186005

Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC- class 1 molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.

On a identifié des antigènes de rejet de tumeur (TRA) dérivés de MAGE-3, précurseur de rejet de tumeur. Ces "TRA" se lient à la molécule HLA-A2, classe 1 du CMH, et les complexes ainsi obtenus stimulent la production de clones de lymphocytes T cytolytiques, lesquels lysent les cellules qui se présentent. Les peptides et les complexes peuvent s'utiliser à des fins diagnostiques, thérapeutiques et comme immunogènes pour la production d'anticorps, ou comme cibles pour la génération de clones de lymphocytes T cytolytiques.

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