Chimeric alpha q-gustducin g-proteins

Details Chimeric alpha q-gustducin g-proteins Chimeric alpha q-gustducin g-proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2507387

G.alpha.q-Gustducin chimeric G-proteins that functionally couple to G-protein coupled receptors. The chimeras can be expressed in heterologous cell systems and can be used as the basis of assays for identifying modulators of taste response, in particular bitter, sweet or umami taste responses.

L'invention concerne des protéines G chimériques G¿.alpha.q-gustducine? qui se couplent fonctionnellement à des récepteurs couplés aux protéines G. Les chimères peuvent être exprimées dans des systèmes cellulaires hétérologues et elles peuvent servir de base à des essais visant à identifier des modulateurs de la réponse gustative, en particulier à l'amer, au sucré ou à l'umami.

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