Stable solid dosage forms of amino acids and processes for...

A - Human Necessities – 61 – K

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A61K 31/195 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2422871

Pharmaceutical formulations, adn processes for making same, comprising an amino acid which is liable to formation of an undesirable lactam, and a stabilizer comprising a volatile alcohol; a non-volatile alcohol; a water immiscible liquid or solid; a liquid with a relatively low dielectric constant; a liquid surface active agent; a solid surface active agent; an antioxidant; a ketone, an aldehyde; a solid polyethylene glycol of high molecular weight; polyvinylpyrrolidone; a derived cellulose; silicon dioxide; or a combination thereof.

L'invention concerne des préparations pharmaceutiques et leurs procédés de production, ces préparations comprenant un acide aminé, susceptible de former un lactame indésirable, et un stabilisateur constitué des éléments suivants : un alcool volatil, un alcool non volatil, un liquide ou un solide non miscible dans l'eau, un liquide à constante diélectrique relativement faible, un tensioactif liquide, un tensioactif solide, un antioxydant, une cétone, un aldéhyde, un glycol polyéthylénique solide de poids moléculaire élevé, du polyvinylpyrrolidone, une cellulose dérivée, du dioxyde de silicium, ou une combinaison de ces éléments.

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