G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) A61K 38/17 (2006.01) A61K 38/40 (2006.01) A61K 38/43 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C07K 14/705 (2006.01) C07K 14/79 (2006.01) C12N 5/00 (2006.01) C12N 9/00 (2006.01) C12P 21/02 (2006.01) C12P 21/06 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G01N 33/90 (2006.01) A61K 38/00 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2139862
The invention relates to a GPI-anchored p97 and a soluble form of p97 and derivatives thereof and methods for preparing the same. Methods of using p97 in modulating iron transport, in the delivery of therapeutic agents, and in the treatment of conditions involving disturbances in iron metabolism are described. The treatment and diagnosis of Alzheimer's Disease in view of the finding that p97 and transferrin receptor are markers for microglial cells associated with senile plaques are also described.
Food Michael R.
Jefferies Wilfred A.
Mcgeer Patrick L.
Rothenberger Sylvia
Yamada Tatsuo
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The University Of British Columbia
University Of British Columbia
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