Substituted benzopyran derivatives and their use as...

Details Substituted benzopyran derivatives and their use as... Substituted benzopyran derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 311/68 (2006.01) A61K 31/35 (2006.01)

Patent

CA 2335846

This invention relates to 6-(hydroxyalkylcarbonyl) benzopyrans of general formula (I), processes for their preparation, their anti-convulsant properties, and their potential use in the treatment and/or prevention of anxiety, mania, depression, panic disorders and/or aggression, disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alcohol and benzodiazepines, disorders treatable and/or preventable with anti- convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson's disease, psychosis, migraine, cerebral ischaemia, Alzheimer's disease and other degenerative diseases such as Huntingdon's chorea, schizophrenia, obsessive compulsive disorders (OCD), neurological deficits associated with AIDS, sleep disorders (including circadian rhythm disorders, insomnia and narcolepsy), tics (e.g. Giles de la Tourette's syndrome), traumatic brain injury, tinnitus, neuralgia, especially trigeminal neuralgia, neuropathic pain, dental pain, cancer pain, inappropriate neuronal activity resulting in neurodysthesias in diseases such as diabetes, multiple sclerosis (MS) and motor neurone disease, amyotrophic lateral sclerosis (ALS), ataxias, muscular rigidity (spasticity), and/or temporomandibular joint dysfunction.

L'invention concerne des 6-(hydroxyalkylcarbonyl)benzopyranes de la formule générale (I), des procédés de préparation desdits composés, leur propriétés anti-convulsives et leur utilisation potentielle dans le traitement et/ou la prévention de l'anxiété, la manie, la dépression, les troubles et/ou agressions paniques, les troubles associés à une hémorragie sous-arachnoïdienne ou un choc neuronal, les effets associés au sevrage de drogues telles que la cocaïne, la nicotine, l'alcool ou les benzodiazépines, les troubles pour lesquels des agents anti-convulsifs peuvent être utilisés comme moyen de traitement ou de prévention (épilepsie, y compris l'épilepsie post-traumatique), la maladie de Parkinson, la psychose, la migraine, l'ischémie cérébrale, la maladie d'Alzheimer ou d'autres maladies dégénératives (telles que la chorée de Huntington), la schizophrénie, les troubles obsessionnels compulsifs, les déficits neurologiques associés au SIDA, les troubles du sommeil (y compris les troubles du rythme circardien, l'insomnie et la narcolepsie), les tics (p. ex. la maladie de Gilles de la Tourette), le traumatisme cérébral, l'acouphène, la nevralgie (en particulier la nevralgie faciale), les douleurs neuropathiques, les douleurs dentaires, les douleurs cancéreuses, l'activité neuronale inappropriée se traduisant par des neurodysthésies dans des maladies telles que le diabète, la sclérose en plaques et les maladies des motoneurones, la sclérose latérale amyotrophique, les ataxies, la rigidité musculaire (spasticité), et/ou les troubles des articulations temporo-mandibulaires.

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