C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/385 (2006.01) A61K 31/4535 (2006.01) A61K 31/535 (2006.01) C07D 333/64 (2006.01)
Patent
CA 2286207
The present invention provides a method of preventing breast carcinoma or cancer in a patient comprising administering a therapeutically effective amount of a compound having the structure (I) in which R1 and R2 are independently hydroxy or alkoxy of one to four carbon atoms; and R3 and R4 are independently methyl or ethyl, or R3 and R4, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl-pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.
Cette invention a trait à une méthode de prophylaxie du carcinome mammaire chez une patiente consistant à administrer à celle-ci une quantité efficace du point de vue thérapeutique d'un composé de la structure (I) dans laquelle R?1¿ et R?2¿ représentent, de manière indépendante, un hydroxy ou un alcoxy comportant de u à quatre atomes de carbone, R?3¿ et R?4¿ représentant, de manière indépendante, un méthyle ou un éthyle ou bien R?3¿ et R?4¿ pris avec l'atome d'azote auquel ils sont rattachés, constituent un noyau pyrrolidino, pyrrolidino-méthyle, pyrrolidino-diméthyle, pipéridino, morpholino ou hexaméthylène-imino.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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