Selective factor xa inhibitors containing a fused azepinone...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 417/12 (2006.01) A61K 31/5513 (2006.01) A61K 31/69 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C07D 243/14 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07F 5/02 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01)

Patent

CA 2299612

Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. They have structure (I), where the meanings of the substituents are as indicated in the text.

La présente invention concerne de nouveaux composés, ainsi que leurs sels et des compositions associées, efficaces contre le facteur Xa mammalien. Ces composés s'avèrent utiles in vitro et in vivo pour prévenir ou traiter les troubles de la coagulation. Ils possèdent la structure représentée par la formule (I), dans laquelle les substituants sont décrits dans le texte de l'invention.

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