Heteroaryl urea derivatives useful for inhibiting chkl

Details Heteroaryl urea derivatives useful for inhibiting chkl Heteroaryl urea derivatives useful for inhibiting chkl

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/497 (2006.01) A61K 31/5355 (2006.01) A61K 31/541 (2006.01) A61P 35/00 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2602199

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.

L'invention concerne des composés d'urée substitués utilisés dans le traitement de maladies et de troubles liés à des dommages à l'ADN ou des lésions dans la réplication de l'ADN. Cette invention a aussi pour objet des méthodes de conception des composés et leur utilisation en tant qu'agents thérapeutiques, par exemple, dans le traitement de cancer et d'autres maladies caractérisées par des défauts dans la réplication de l'ADN, la ségrégation chromosomique ou la division cellulaire.

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