G - Physics – 01 – N
Patent
G - Physics
01
N
324/26
G01N 27/42 (2006.01) G01N 33/487 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2002660
ABSTRACT OF THE DISCLOSURE A method of detecting a substance in a test sample, which substance is one of a pair of substances that undergo a specific binding reaction with each other, in- cludes the steps of reacting the test sample with a reagent comprising the other of the pair of substances and determin- ing the extent of reaction therebetween. Particles having a first one of the pair of substances bound to the surfaces thereof are contacted with a layer of the second substances which substantially spans a path between a pair of spaced- apart electrical conductors superposed on a substantially non-electrically conductive base. Each of the conductors is connected to means forming an electrical circuit which in- cludes the conductors and the path therein. The binding reaction between said first and second substances causing the particles to be bound to the bottom wall to form aggre- gates. Unbound particles are removed, and exposed outer surfaces of said aggregates are coated with an electrically conductive substance. A change in the electrical current flow through the circuit caused by formation of the coated aggregates on the path is measured. This electrical change indicates the level of the substance to be detected in the test sample.
Mroczkowski Susan J.
Siegesmund Kenneth A.
Yorde Donald E.
Immunotronics Inc.
Mroczkowski Susan J.
Shapiro Cohen
Siegesmund Kenneth A.
Yorde Donald E.
LandOfFree
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