Use of compounds containing thiol groups as an efflux pump...

Details Use of compounds containing thiol groups as an efflux pump... Use of compounds containing thiol groups as an efflux pump...

A - Human Necessities

61

K

A61K 31/7048 (2006.01) A61K 31/716 (2006.01) A61K 31/717 (2006.01) A61K 31/795 (2006.01) A61K 38/03 (2006.01) A61K 38/06 (2006.01) A61K 38/13 (2006.01) A61K 38/33 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2574232

The non-invasive administration of many active ingredients fails with efflux pumps which sharply reduce the active ingredient resorption on mucous membranes. According to the invention, the active ingredient resorption on mucous membranes can be drastically improved by using dosages containing glutathione and/or compounds comprising numerous thiol groups, in addition to the active ingredient(s). Forms of administration such as matrix tablets, capsules, eye drops, or microparticles, containing the cited combination of active ingredients and auxiliary substances, can be used.

L'administration non invasive de nombreux principes actifs échoue en raison des pompes d'efflux qui réduisent fortement la résorption des principes actifs à travers les muqueuses. L'utilisation de formes galéniques qui contiennent, outre un ou plusieurs principes actifs, du glutathion et / ou des composés contenant de nombreux groupes thiol, permet d'améliorer considérablement la résorption des principes actifs à travers les muqueuses. Les formes galéniques utilisées peuvent être par exemple des comprimés à matrice, des capsules, des gouttes pour les yeux ou des microparticules qui contiennent la combinaison susmentionnée de principes actifs et d'adjuvants.

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