A method for improving the pharmaceutic properties of...

Details A method for improving the pharmaceutic properties of... A method for improving the pharmaceutic properties of...

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 9/16 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2643464

Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.

L'invention concerne des procédés de séchage d'une particule. Plus spécifiquement, l'invention concerne une formulation particulaire à base de dicétopipérazine et d'insuline desséchée par atomisation, présentant des performances aérodynamiques améliorées, et dans laquelle l'agent actif est plus stable et plus efficacement administré comparé à celui de la formulation à base de dicétopipérazine et d'insuline lyophilisée. Les poudres sèches sont utiles en tant que formulations pharmaceutiques pour l'administration pulmonaire.

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