Neisserial antigenic peptides

Details Neisserial antigenic peptides Neisserial antigenic peptides

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/095 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2389321

This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

L'invention concerne, entre autres, des protéines, des polypeptides, et leurs fragments, dérivés de la bactérie Neisseria meningitidis B. L'invention concerne également des acides nucléiques codant ces protéines, polypeptides et/ou fragments, ainsi que des acides nucléiques complémentaires (par exemple, acides nucléiques antisens). L'invention concerne en outre des anticorps se liant à ces protéines, polypeptides et/ou fragments, ainsi que des vecteurs d'expression utiles pour l'élaboration des protéines, polypeptides et/ou fragments en question, et des cellules hôtes transformées par ces vecteurs. L'invention concerne également des compositions de ces protéines, polypeptides, fragments, et/ou acides nucléiques, utilisées pour différentes applications: vaccins, réactifs diagnostiques, compositions imunogéniques, et autres. L'invention concerne par ailleurs des procédés relatifs à l'élaboration des compositions considérées et des procédés de traitement reposant sur l'utilisation desdites compositions. L'invention concerne enfin des procédés relatifs à la détection des protéines, polypeptides, fragments et/ou acides nucléiques décrits.

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