The preparation of carboxylic acid derivatives

Details The preparation of carboxylic acid derivatives The preparation of carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/79 (2006.01) C07C 67/22 (2006.01) C07C 69/675 (2006.01) C07C 231/06 (2006.01) C07C 235/06 (2006.01) C07D 211/60 (2006.01) C07D 213/80 (2006.01) C07D 213/803 (2006.01) C07D 213/81 (2006.01) C07D 231/14 (2006.01) C07D 233/90 (2006.01) C07D 265/30 (2006.01)

Patent

CA 2218134

A process is disclosed for preparing carboxylic acid derivatives having the general formula (I), in which X stands for OR2 or NH2, R1 stands for C1-C20 alkyl, C1-C20 hydroxyalkyl, C3-C12-cycloalkyl, C4-C12 alkyl-cycloalkyl, C4-C12-cycloalkyl- alkyl, C5-C20 alkyl-cycloalkyl-alkyl, aryl, C7-C20 aralkyl, C7-C20 alkylaryl, an heteroaliphatic or heteroaromatic ring with 5 to 8 carbon atoms and R2 stands for C1-C20 alkyl, from carboxylic acid nitriles having the general formula (II) R1-C.ident.N, in which R1 has the above-mentioned meanings, and from alcohols having the general formula (III) R2-OH, in which R2 has the above-mentioned meanings. The reaction is carried out in the liquid phase at temperatures from 50 to 300 °C and pressures from 0.1 to 350 bars in the presence of an heterogeneous catalyst.

Ce procédé permet de préparer des dérivés d'acide carboxylique ayant la formule générale (I), dans laquelle X désigne OR<2> ou NH2, R<1> désigne alkyle C1-C20, hydroxyalkyle C1-C20, cycloalkyle C3-C12, alkyle-cycloalkyle C4-C12, cycloalkyle-alkyle C4-C12, alkyle-cycloalkyle-alkyle C5-C20, aryle, aralkyle C7-C20, alkylaryle C7-C20, un cycle hétéroaliphatique ou hétéroaromatique avec 5 à 8 atomes de carbone; et R<2> désigne alkyle C1-C20, à partir de nitriles d'acide carboxylique ayant la formule générale (II) R<1>-CN, dans laquelle R<1> a les significations susmentionnées, et d'alcools ayant la formule générale (III) R<2>-OH, dans laquelle R<2> a les significations susmentionnées. On procède à la réaction dans la phase liquide à des températures comprises entre 50 et 300 DEG C et sous des pressions de 0,1 à 350 bars en présence d'un catalyseur hétérogène.

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