Therapeutic gpcr targets in cancer

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) C40B 40/08 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2516138

The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. This invention relates to G-protein coupled receptor (GPCR) sequences. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

La présente invention a trait à de nouvelles séquences utilisables dans la détection, le diagnostic et le traitement des cancers, notamment des lymphomes. L'invention propose des séquences polynucléotidiques associées au cancer dont l'expression est associée au cancer. La présente invention a trait à des polypeptides associés liés au cancer qui sont présents à la surface cellulaire et propose de nouvelles cibles thérapeutiques contre le cancer. L'invention a également trait à des séquences de récepteur de couplage à la protéine G. La présente invention a trait en outre à des compositions de diagnostic et des procédés pour la détection du cancer. La présente invention a trait à des anticorps monoclonaux et polyclonaux spécifiques des polypeptides associés au cancer. La présente invention a également trait à des outils de diagnostic et des compositions thérapeutiques et des procédés de dépistage, de prévention et de traitement du cancer.

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