Substituted 2-phenyl-pyridine derivatives

Details Substituted 2-phenyl-pyridine derivatives Substituted 2-phenyl-pyridine derivatives

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/44 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2719636

The present invention re-lates to compounds of formula (I) where-in R1, R2, R4, R5, R a, R b, n, W and Z are as defined in the application, their prepa-ration and their use as P2Y12 receptor antagonists in the treatment and/or pre-vention of peripheral vascular, of viscer-al-, hepatic- and renal-vascular, of car-diovascular and of cerebrovascular dis-eases or conditions associated with platelet aggregation, including thrombo-sis in humans and other mammals.

La présente invention concerne des composés de formule (I) dans laquelle R1, R2, R4, R5, Ra, Rb, n, W et Z sont tels que définis dans la demande, leur préparation et leur utilisation comme antagonistes du récepteur P2Y12 dans le traitement et/ou la prévention des maladies vasculaires périphériques, viscéro-vasculaires, hépato-vasculaires et réno-vasculaires, cardiovasculaires et cérébrovasculaires ou des états associés à lagrégation plaquettaire, y compris la thrombose chez les humains et les autres mammifères.

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