Human endogenous retrovirus in breast cancer

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/15 (2006.01) C07K 14/47 (2006.01) C07K 16/08 (2006.01) C07K 16/18 (2006.01) C12N 15/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2369848

The present invention is related to mammary tumor virus (MTV). MTV represents a group of retroviruses which possess very high homology to mouse mammary tumor virus (MMTV), a virus known to cause neoplastic mammary disease in mice. As described herein, MTV's have been identified in human, cat, and Rhesus macaque. The present invention specifically provides for recombinant nucleic acids and polypeptides derived from these MTV's as well as methods for using these biological molecules.

La présente invention concerne le virus de la tumeur mammaire (VTM). Le VTM représente un groupe de rétrovirus qui présente une homologie très forte avec le virus de la tumeur mammaire chez la souris (VTMS), ce virus étant connu pour provoquer chez la souris une maladie mammaire néoplasique. On a identifié des VTM chez l'homme, le chat et le macaque Rhésus. Cette invention concerne de manière spécifique des acides nucléiques de recombinaison et des polypeptides dérivés de ces VTM ainsi que des procédés d'utilisation de ces molécules biologiques.

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