Crystallization and structure determination of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/53 (2006.01) C12N 9/04 (2006.01) C12Q 1/32 (2006.01)

Patent

CA 2378032

The substrate free form of Staphylococcus aureus UDP-N- acetylenolpyruvylglucosamine reductase S. ureus MurB has been crystallized, and the three dimensional x-ray crystal structure has been solved to 2.3 .ANG. resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of S. aureus MurB.

Selon l'invention, la forme exempte substrat de Staphylococcus aureus UDP-N-acétylénolpyruvylglucosamine réductase (S. aureus MurB) a été cristallisée, une structure cristalline tridimensionnelle obtenue par cristallographie aux rayons X ayant été résolue à une résolution de 2,3.ANG.. Cette structure cristalline obtenue par cristallographie aux rayons X est utile pour résoudre la structure d'autres molécules ou complexes moléculaires, et pour désigner des inhibiteurs de S. aureus MurB.

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