Phenazine and quinoxaline substituted amino acids and...

Details Phenazine and quinoxaline substituted amino acids and... Phenazine and quinoxaline substituted amino acids and...

C - Chemistry, Metallurgy

07

D

C07D 241/40 (2006.01) C07D 401/14 (2006.01) C07D 487/12 (2006.01)

Patent

CA 2671851

Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a phenazine or quinoxaline substituent. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides.

L'invention concerne des acides aminés et des polypeptides non naturels qui comprennent au moins un acide aminé non naturel, et des procédés de fabrication de ces acides aminés et polypeptides non naturels. Les acides aminés non naturels, seuls ou formant un polypeptide, peuvent comprendre un substituant phénazine ou quinoxaline. L'invention concerne aussi des polypeptides d'acides aminés non naturels qui sont modifiés davantage de manière post-traductionnelle, des procédés de mise en AEuvre de telles modifications et des procédés de purification de tels polypeptides.

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