Squalene synthetase inhibitory composition and use thereof

Details Squalene synthetase inhibitory composition and use thereof Squalene synthetase inhibitory composition and use thereof

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/66 (2006.01) A61K 31/665 (2006.01) A61K 31/675 (2006.01) C07F 9/40 (2006.01) C07F 9/58 (2006.01) C07F 9/6506 (2006.01) C07F 9/6512 (2006.01) C07F 9/6524 (2006.01) C07F 9/6539 (2006.01) C07F 9/6541 (2006.01) C07F 9/655 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2082144

Abstract of the disclosure: There is provided a squalene inhibitory composition containing 1,1-bisphosphonic acid compound, a lower alkyl ester thereof or a salt thereof, which is useful as a treating agent for hypercholesterolemia. There are also provided novel compounds having squalene synthetase inhibitory activity and a pharmaceutical composition for treating hypercholesterolemia containing a 1,1-bisphosphonic compound, a lower alkyl ester thereof or a salt thereof.

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