C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61K 31/4525 (2006.01) C07D 405/06 (2006.01)
Patent
CA 2426221
The invention relates to new compounds of formula I (see formula I) or the pharmaceutically acceptable salts thereof, wherein R1 denotes 3-hydroxypropyl, 1,3-dihydroxyprop-2-yl or C3-C6-cycloalkylmethyl, and R2, R3, R4 and Ar have the meanings given in the specification, as well as the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin) antagonists.
La présente invention concerne de nouveaux composés de formule (I) ou des sels de ceux-ci, acceptables d'un point de vue pharmaceutique. Dans la formule (I), R<1> représente 3-hydroxypropyle, 1,3-dihydroxyprop-2-yle ou cycloalkylméthyle C3-C6 et R<2>, R<3>, R<4> et Ar ont les significations énoncées dans la description. La présente invention concerne également la production et l'utilisation de ces composés. Les nouveaux composés selon cette invention constituent de précieux antagonistes de neurokinine (tachykinine) à action prolongée.
Dollinger Horst
Esser Franz
Jung Birgit
Schromm Kurt
Speck Georg
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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