Modified protamine with reduced immunogenicity

Details Modified protamine with reduced immunogenicity Modified protamine with reduced immunogenicity

A - Human Necessities

61

K

A61K 38/16 (2006.01) C07K 14/46 (2006.01)

Patent

CA 2439929

The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of protamine to result in protamine proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

L'invention concerne des polypeptides destinés à être administrés spécialement à des patients humains et convenant en particulier pour des utilisations thérapeutiques. Ces polypeptides sont des polypeptides modifiés, ces modifications se traduisant par une propension réduite du polypeptide à provoquer une réponse immunitaire après avoir été administré à un sujet humain. L'invention concerne en particulier la modification de protamines, permettant de produire des protéines de protamines qui sont sensiblement non immunogènes ou moins immunogènes que leurs homologues non modifiés lorsqu'ils sont utilisés in vivo.

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