2-substituted adenosine derivatives and pharmaceutical...

Details 2-substituted adenosine derivatives and pharmaceutical... 2-substituted adenosine derivatives and pharmaceutical...

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 31/70 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2056596

Disclosed herein are a novel 2-substituted adenosine derivative having the following formula [I] Image wherein R represents a hydrogen atom or a hydroxyl group, m is an integer of 2 to 7, n is 0 or an integer of 1 to 3, and R1, R2 and R3, which may be the same or different, each independently represent a hydrogen atom, a hydroxy protective group or a phosphoric acid residue, and salts thereof. The above compounds are excellent in a circulation ameliorating effect such as a vasodepressor activity, and have high selectivity for A2 receptors, but cause less undesirable side effects such as a suppressive effect on the heart. They are therefor effective when used in pharmaceutical compositions for circulatory diseases.

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