Pyrazolo[3,4-b]pyridin-6-ones as gsk-3 inhibitors

Details Pyrazolo[3,4-b]pyridin-6-ones as gsk-3 inhibitors Pyrazolo[3,4-b]pyridin-6-ones as gsk-3 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2529083

The invention provides compounds of formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R1, R2, and R3 are as defined herein; pharmaceutical compositions thereof; and use thereof in the treatment of, inter alia, conditions, diseases, and symptoms such as diabetes, dementia, Alzheimer's Disease, stroke, schizophrenia, depression, hair loss, and cancer.

La présente invention se rapporte à des composés répondant à la formule (I), leurs stéréoisomères et promédicaments, et les sels pharmaceutiquement acceptables de ces composés, stéréoisomères et promédicaments, R?1¿, R?2¿ et R?3¿ dans ladite formule (I) ayant les notations définies dans la demande; compositions pharmaceutiques les contenant ; et leur utilisation dans le traitement, entre autres, des affections, maladies et symptômes tels que le diabète, la démence, la maladie d'Alzheimer, les accidents vasculaires cérébraux, la schizophrénie, la dépression, l'alopécie et les cancers.

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