A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/433 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 38/55 (2006.01) A61K 45/06 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2368650
A pharmaceutical composition that inhibits or slows the infection or reinfection of animals, particularly mammals, by HIV or other retroviruses is disclosed. The composition comprises from about 10 mg to about 6000 mg of a (5-aryl-1,2,4-thiadiazol)-3-yl thiourea derivative or (5-aryl- 1,2,4-thiadiazol)-3-yl urea derivative of formula: (I), wherein X is oxygen or sulfur, R is hydrogen or alkyl having from 1-3 carbons, n is 1-4, R is independently selected from the group consisting of hydrogen, alkyl having from 1 to 7 carbon atoms, chloro, bromo or fluoro, oxychloro, alkoxy having the formula -O(CH2)CH wherein y is from 1 to 6, or a pharmaceutically acceptable acid addition salt or prodrug thereof. The preferred compound is (5-phenyl-1,2,4-thiadazol-3-yl) thiourea. These pharmaceutical compositions maa also further contain other antiviral adjunct therapy such as AZT, 3-Tc (lamicudine) or protease inhibitors.
L'invention concerne une composition pharmaceutique inhibant ou ralentissant l'infection ou la réinfection d'animaux, notamment des mammifères, par le VIH ou d'autres rétrovirus. Cette composition comprend environ 10 à environ 6000 mg d'un dérivé de (5-aryl-1,2,4-thiadiazol)-3-yl-thiourée ou d'un dérivé de (5-aryl-1,2,4-thiadiazol)-3-yl-urée, correspondant à la formule (I) dans laquelle X représente oxygène ou soufre, R représente hydrogène ou alkyle possédant 1 à 3 atomes de carbone, n vaut 1 à 4, R1 est choisi indépendamment dans le groupe constitué par hydrogène, alkyle possédant 1 à 7 atomes de carbone, chloro, bromo ou fluoro, oxychloro, alcoxy possédant la formule -O(CH2)YCH3 où y vaut de 1 à 6. L'invention concerne également un sel d'addition d'acide ou un promédicament de ce composé. Le composé que l'on préfère est une (5-phényl-1,2,4-thiadazol-3-yl)thiourée.
Dimock Stratton Llp
The Procter & Gamble Company
Uaf Technologies And Research Llc
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