A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2522104
The present invention provides a method for preventing or treating acute or chronic graft rejection in a recipient of cell, tissue or organ allo- or xenotransplant, inflammatory or autoimmune diseases or malignant proliferative disease, comprising the use of an inhibitor of Vav. Further provided are Vav inhibitors, uses, pharmaceutical compositions and therapeutic combinations comprising Vav inhibitors, and screening methods therefor.
L'invention concerne un procédé permettant de prévenir ou de traiter un rejet de greffe aigu ou chronique chez un sujet ayant subi une allogreffe ou une xénogreffe de cellules, de tissus ou d'organes; des maladies inflammatoires ou auto-immunes, ou des maladies prolifératives malignes. Ce procédé consiste à utiliser un inhibiteur de la protéine Vav. L'invention concerne en outre des inhibiteurs de la protéine Vav, des utilisations, des compositions pharmaceutiques et des combinaisons thérapeutiques comprenant lesdits inhibiteurs de la protéine Vav, ainsi que des procédés de criblage associés.
Forstner Michael
Klumpp Martin
Leder Lukas
Nusslein-Hildesheim Barbara
Raulf Friedrich
Fetherstonhaugh & Co.
Novartis Ag
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