Transformed endothelial cells

Details Transformed endothelial cells Transformed endothelial cells

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2143489

Endothelial cells which express a protein having I?B activity such that NF?B activation of the cells is substantially blocked may be prepared by altering the genetic material of the cells so that I?B activity is expressed continuously, immediately following endothelial cell activiting stimuli or on demand in response to a predetermined external stimulus e.g. by introducing he- terologous I?B coding sequences or promoters into the cells. Organs and tissue comprising such endothelial cells are useful in transplantation e.g. xenotransplantation, as they are advantageously less susceptible to rejection.

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