Pyrimidine derivatives and processes for the preparation...

Details Pyrimidine derivatives and processes for the preparation... Pyrimidine derivatives and processes for the preparation...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2266519

4-Amino-lH-pyrazolo[3,4-d]pyrimidine derivatives of formula (I) wherein the substituents are as defined in claim 1, are described. These compounds inhibit the tyrosine kinase activity of the receptor for epidermal growth factor (EGF) and c-erbB2 kinase and can be used as anti-tumour agents.

L'invention concerne les dérivés de 4-Amino-1H-pyrazolo(3,4-d)pyrimidine présentant la formule (I), dans lesquels les substituents sont tels que définis dans la revendication 1. Ces composés inhibent l'activité de la tyrosine kinase du récepteur du facteur de croissance épidermique et de la kinase c-erbB2 et peuvent être utilisés comme agents anti-tumoraux.

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