Synbiotic to improve gut microbiota

A - Human Necessities – 61 – K

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A61K 39/05 (2006.01) A23L 1/30 (2006.01)

Patent

CA 2680093

The use of a probiotic strain of Lactobacillus rhamnosus and an oligosaccharide mixture which comprises 5-70 wt% of at least one N-acetylated oligosaccharide selected from the group comprising GalNAc.alpha.l,3Gal.beta.l,4Glc and Gal.beta.l,6GalNAc.alpha.l,3Gal.beta.l,4Glc, 20-90 wt% of at least one neutral oligosaccharide selected from the group comprising Gal.beta.l,6Gal, Gal.beta.l,6Gal.beta.l,4Glc Gal.beta.l,6Gal.beta.l,6Glc, Gal.beta.l,3Gal.beta.l,3Glc, Gal.beta. 1,3Gal.beta. 1,4GIc, Gal.beta. 1,6Gal.beta. 1,6Gal.beta. 1,4GIc, Gal.beta. 1,6Gal.beta. 1,3Gal.beta. 1,4GIc Gal.beta.l,3Gal.beta.l,6Gal.beta.l,4Glc and Gal.beta. l,3Gal.beta.l,3Gal.beta.l, 4GIc and 5-50 wt% of at least one sialylated oligosaccharide selected from the group comprising NeuAc.alpha.2,3Gal.beta.l,4Glc and NeuAc.alpha.2,6Gal.beta.l,4Glc in the manufacture of a medicament or therapeutic nutritional composition for promoting the development of an early bifidogenic intestinal microbiota in infants delivered by caesarean section is disclosed.

La présente invention concerne l'utilisation d'une souche probiotique de Lactobacillus rhamnosus et d'un mélange d'oligosaccharides qui comprend de 5 à 70 % en poids d'au moins un oligosaccharide N-acétylé sélectionné dans le groupe comprenant GalNAc.alpha.1,3Gal.beta.1,4Glc et Gal.beta.1,6GalNAc.alpha.1,3Gal.beta.1,4Glc, de 20 à 90 % en poids d'au moins un oligosaccharide neutre sélectionné dans le groupe comprenant Gal.beta.1,6Gal, Gal.beta.1,6Gal.beta.1,4Glc, Gal.beta.1,6Gal.beta.1,6Glc, Gal.beta.1,3Gal.beta.1,3Glc, Gal.beta.1,3Gal.beta.1,4GIc, Gal.beta.1,6Gal.beta.1,6Gal.beta.1,4GIc, Gal.beta.1,6Gal.beta.1,3Gal.beta.1,4GIc, Gal.beta.1,3Gal.beta.1,6Gal.beta.1,4Glc et Gal.beta.1,3Gal.beta.1,3Gal.beta.1,4GIc et de 5 à 50% en poids d'au moins un oligosaccharide sialylé sélectionné dans le groupe comprenant NeuAc.alpha.2,3Gal.beta.1,4Glc et NeuAc.alpha.2,6Gal.beta.1,4Glc dans la fabrication d'un médicament ou d'une composition nutritionnelle thérapeutique servant à promouvoir le développement d'un microbiote intestinal bifidogène précoce chez les enfants nés par césarienne.

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