Use of il-21 in cancer and other therapeutic applications

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/20 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2487133

Methods for treating mammals with cancer and infections using molecules that have an IL-21 functional activity are described. The molecules having 11-21 functional activities include polypeptides that have homology to the human IL 21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer or viral therapeutics.

L'invention concerne des méthodes de traitement de mammifères souffrant de cancers et d'infections au moyen de molécules qui présentent une activité fonctionnelle d'Il-21. Lesdites molécules présentant des activités fonctionnelles d'IL-21 comprennent des polypeptides qui présentent une homologie avec la séquence de polypeptides d'IL-21 et des protéines fusionnées à un polypeptide présentant une activité fonctionnelle d'IL-21. Lesdites molécules peuvent être utilisées en tant que monothérapie ou en combinaison avec d'autres thérapeutiques connues contre le cancer ou des virus.

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