Methods for increasing neisseria protein expression

Details Methods for increasing neisseria protein expression Methods for increasing neisseria protein expression

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/095 (2006.01) C07K 14/22 (2006.01) C12N 15/67 (2006.01) C12N 15/70 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2512917

The present invention broadly relates to polynucleotide sequences encoding porin polypeptides of Neisseria. More particularly, the invention relates to nucleic acid sequence mutations in polynucleotides encoding PorA polypeptides of Neisseria meningitidis, wherein these sequence mutations result in increased expression levels of PorA polypeptides.

La présente invention concerne, au sens large, des séquences de polynucléotides codant des polypeptides de la porine de Neisseria. Plus spécifiquement, cette invention a trait à des mutations de séquences d'acides nucléiques récemment identifiées dans des polynucléotides codant des polypeptides PorA de Neisseria meningitidis, ces mutations de séquences débouchant sur des niveaux d'expression augmentés de polypeptides PorA.

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