Substituted 1,2,3,4-tetrahydroisoquinoline derivatives

Details Substituted 1,2,3,4-tetrahydroisoquinoline derivatives Substituted 1,2,3,4-tetrahydroisoquinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 217/18 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2557163

The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) wherein R1, R2, R3 and X are as defined in the claims, and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.

La présente invention a trait à de nouveaux dérivés de 1,2,3,4-tétrahydroisoquinoléine de formule (I), dans laquelle R?1¿, R?2¿, R?3¿ et X sont tels que définis dans les revendications, et à leur utilisation en tant que principes actifs dans la préparation de compositions pharmaceutiques. L'invention a également trait à des aspects associés comprenant des procédés pour la préparation des composés, à des compositions pharmaceutiques contenant un ou plusieurs desdits composés et à des procédés de traitement comprenant l'administration desdits composés à un mammifère.

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