Spiro-substituted azacyclic-substituted piperazino...

Details Spiro-substituted azacyclic-substituted piperazino... Spiro-substituted azacyclic-substituted piperazino...

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/445 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2275163

The invention relates to compounds of formula (I), wherein Z, Rc, y, m, u, Ar1, n, X, Rc', I and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

L'invention porte sur des composés de formule (I) dans laquelle Z, R¿c?, y, m, u, Ar¿1?, n, X, R¿c'? I et Ar¿2? sont explicités dans la description. Lesdits composés, des antagonistes de la neuroquinine, traitent les maladies chroniques des voies aériennes, telles que l'asthme.

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