Cyclopentyl modulators of chemokine receptor activity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 211/32 (2006.01) A61K 31/445 (2006.01) A61K 31/451 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/38 (2006.01) C07D 211/40 (2006.01) C07D 211/52 (2006.01) C07D 211/60 (2006.01) C07D 217/04 (2006.01) C07D 221/20 (2006.01) C07D 295/155 (2006.01) C07D 401/08 (2006.01) C07D 401/12 (2006.01) C07D 413/08 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2419194

The present invention is directed to compounds of the formula I (wherein R1, R2, R3, R4, R5, R6 and X are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

L'invention concerne des composants de formule I (dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ et X sont définis dans le présent texte) qui servent de modulateurs de l'activité du récepteur de la chimiokine. L'invention concerne en particulier ces composants utilisés comme modulateurs du CCR-2, récepteur de la chimiokine.

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