C - Chemistry – Metallurgy – 22 – B
Patent
C - Chemistry, Metallurgy
22
B
C22B 60/00 (2006.01) C22B 3/24 (2006.01)
Patent
CA 2662932
The present application is directed to a method for the purification of Radium, in particular 226Ra1 for target preparation for an essentially pure 225Ac production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is further related to a method for recycling of 226Ra, for target preparation for 225Ac production from radium sources irradiated with accelerated protons (p,2n), after separation of the produced 225Ac. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtained 226Ra is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li1 Mg1 Mn, Na1 Ni1 Pb1 Sr1 V, Zn, and Ba.
La présente invention concerne un procédé pour la purification du radium, en particulier du 226Ra1, pour la préparation cible d'une production de 225Ac sensiblement pur à partir de sources radioactives disponibles, ceci à l'aide d'une chromatographie d'extraction afin de séparer du Ra désiré des éléments chimiquement similaires tels que le Ba, le Sr et le Pb ; ladite chromatographie d'extraction possède un système d'extraction reposant sur un éther couronne. L'invention concerne en outre un procédé pour recycler le 226Ra, pour la préparation cible d'une production de 225Ac à partir de sources de radium irradiées par des protons accélérés (p, 2n) après séparation du 225Ac obtenu. Dans ce procédé, on utilise une combinaison de la chromatographie d'extraction ci-dessus et d'une chromatographie à échange de cations. Le 226Ra obtenu est essentiellement exempt des contaminants chimiques suivants comprenant Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li1, Mg1, Mn, Na1, Ni1, Pb1, Sr1, V, Zn et Ba.
Henkelmann Richard
Kabai Eva
Moreno Bermudez Josue Manuel
Tuerler Andreas
Actinium Pharmaceuticals Inc.
Borden Ladner Gervais Llp
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