Substituted 2-oxo-alkanoic acid-[2-(indol-3-yl)-ethyl] amides

Details Substituted 2-oxo-alkanoic acid-[2-(indol-3-yl)-ethyl] amides Substituted 2-oxo-alkanoic acid-[2-(indol-3-yl)-ethyl] amides

C - Chemistry, Metallurgy

07

D

C07D 209/16 (2006.01) A61K 31/40 (2006.01) C07D 209/14 (2006.01)

Patent

CA 2328875

The invention relates to novel substituted 2-oxo- alkanoic acid-[2- (indol-3- yl)- ethyl] amides of general formula (I), wherein R1 represents optionally branched C1-C8-alkyl or C4-C8-cycloalkyl, R2 represents hydrogen, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-thioalkyl, phenyl or halogen independently of R3, R3 represents hydrogen, C1-C4-alkyl or halogen and R4 represents optionally branched C1-C6-alkyl or C4-C6-cycloalkyl, phenyl which has been optionally substituted once to three times by C1-C3-alkyl, C1-C3-alkoxy, C1-C3-thioalkyl, halogen, nitro or amino or benzyl which has been optionally substituted once to three times by C1-C3-alkyl, C1-C3-alkoxy, C1-C3-thioalkyl, halogen, nitro or amino. The invention also relates to methods for producing the inventive compounds and to the use of said compounds in antibacterial agents.

L'invention concerne de nouveaux acide alcane-2-oxo[2-(indol-3-yl)-éthyl]amides correspondant à la formule générale (I), dans laquelle: R?1¿ représente alkyle C¿1?-C¿8? éventuellement ramifié ou cycloalkyle C¿4?-C¿8?; R?2¿ représente, indépendamment de R?3¿, hydrogène, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4?, phényle ou halogène; R?3¿ représente hydrogène, alkyle C¿1?-C¿4? ou halogène; et R?4¿ représente alkyle C¿1?-C¿6? éventuellement ramifié, cycloalkyle C¿4?-C¿6?, phényle éventuellement substitué d'une à trois fois par alkyle C¿1?-C¿3?, alcoxy C¿1?-C¿3?, thioalkyle C¿1?-C¿3?, halogène, nitro ou amino, ou bien benzyle éventuellement substitué d'une à trois fois par alkyle C¿1?-C¿3?, alcoxy C¿1?-C¿3?, thioalkyle C¿1?-C¿3?, halogène, nitro ou amino. L'invention concerne également un procédé de production de ces composés et leur utilisation dans des agents antibactériens.

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