Polyepitope carrier protein

Details Polyepitope carrier protein Polyepitope carrier protein

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A01K 67/027 (2006.01) A61K 31/715 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) C07K 14/02 (2006.01) C07K 14/11 (2006.01) C07K 14/22 (2006.01) C07K 14/235 (2006.01) C07K 14/33 (2006.01) C07K 14/34 (2006.01) C07K 14/445 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2326376

The invention relates to polyepitope carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are use useful as components of vaccines that can elicit a T- cell dependent immune response. These vaccines are particularly useful to confer protection against infection from encapsulated bacteria in infants between the ages of 3 months and about 2 years.

L'invention a trait à des protéines porteuses de polyépitopes qui comportent au moins cinq épitopes de cellules T-CD4+, utiles pour une conjugaison à des polysaccharides capsulaires. Les protéines porteuses sont utiles comme constituants de vaccins pouvant déclencher une réaction immunitaire dépendant des cellules T. Ces vaccins sont particulièrement utiles pour conférer une protection contre des infections provoquées par des bactéries encapsulées chez des enfants agés de 3 mois à environ 2 ans.

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