Nucleotide analog compositions

Details Nucleotide analog compositions Nucleotide analog compositions

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/675 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2298057

The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its formulation into therapeutic dosages. Invention compositions include an anhydrous crystal form of adefovir dipivoxil.

L'invention concerne des formes cristallines d'adéfovir dipivoxil et des procédés de préparation de ces cristaux. Les compositions et procédés décrits présentent les propriétés souhaitables pour la synthèse adéfovir dipivoxil à grande échelle ou pour sa formulation en doses thérapeutiques. Les compositions décrites comprennent une forme cristalline anhydre d'adéfovir dipivoxil.

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