2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2h-1-...

Details 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2h-1-... 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2h-1-...

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2122494

2122494 9412493 PCTABS00032 2,2-Di(C1-5alkyl)- and trans-2,2-di(C1-5alkyl)-3,4-dihydro-3-hydroxy- -6-(pyridin-4-yl)-2H-1-benzopyrans, e.g. of formula (I) in which R1 and R2 = H, alkyl, hydroxyalkyl or alkoxyalkyl, at least one being other than H, R3 = typically a 2-piperidinone group, R4 = H and R5 = -OH or R4 + R5 = an additional bond, and R6, R7 are alkyl and R8 is H or alkyl, and N-oxides, esters and salts thereof, processes for their production and their uses as pharmaceuticals e.g. as K+-channel openers, bronchodilators and asthma prophylactic agents.

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